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O Hermine Selected Research

masitinib

1/2018Decrease of cocaine, but not heroin, self-administration and relapse by the tyrosine kinase inhibitor masitinib in male Sprague Dawley rats.
6/2015A randomized, placebo-controlled phase III trial of masitinib plus gemcitabine in the treatment of advanced pancreatic cancer.
9/2014Masitinib in advanced gastrointestinal stromal tumor (GIST) after failure of imatinib: a randomized controlled open-label trial.
6/2012Masitinib demonstrates anti-proliferative and pro-apoptotic activity in primary and metastatic feline injection-site sarcoma cells.
1/2012Masitinib as a chemosensitizer of canine tumor cell lines: a proof of concept study.
3/2011Safety of masitinib mesylate in healthy cats.
8/2010Churg and Strauss vasculitis in the course of masitinib treatment: a first report.
9/2009Phase 1 dose-escalation study of oral tyrosine kinase inhibitor masitinib in advanced and/or metastatic solid cancers.
8/2009Masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics.
11/2008Masitinib is safe and effective for the treatment of canine mast cell tumors.

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O Hermine Research Topics

Disease

11Neoplasms (Cancer)
10/2014 - 10/2000
10Lymphoma (Lymphomas)
01/2015 - 04/2000
8Mastocytosis
09/2019 - 06/2004
7Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)
01/2008 - 04/2000
6Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
09/2016 - 04/2002
5Systemic Mastocytosis
09/2019 - 06/2004
5Infections
01/2018 - 01/2004
5Inflammation (Inflammations)
11/2016 - 08/2009
4Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
02/2013 - 06/2006
3Leukemia
01/2009 - 10/2000
2Osteoporosis
06/2019 - 10/2010
2Asthma (Bronchial Asthma)
12/2018 - 08/2009
2Graft vs Host Disease (Graft-Versus-Host Disease)
01/2017 - 12/2002
2Pancreatic Neoplasms (Pancreatic Cancer)
06/2015 - 01/2012
2Malnutrition (Nutritional Deficiencies)
01/2015 - 11/2010
2Disease Progression
10/2014 - 04/2003
2Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
05/2014 - 03/2008
2Hemorrhage
05/2012 - 01/2010
2Breast Neoplasms (Breast Cancer)
02/2010 - 03/2009
2Cardiotoxicity
02/2010 - 05/2002
2Myeloproliferative Disorders (Myeloproliferative Disorder)
01/2007 - 06/2004
1Cytopenia
01/2022
1COVID-19
01/2021
1Cutaneous Mastocytosis
01/2021
1Cocaine-Related Disorders (Cocaine Addiction)
01/2018
1Hypoxia (Hypoxemia)
06/2017
1Hypoalbuminemia
11/2016
1Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
11/2016
122q11 Deletion Syndrome
11/2016
1Mast Cell Activation Disorders (Mast-Cell Disease)
03/2016
1Pain (Aches)
06/2015
1Adenocarcinoma
06/2015
1Residual Neoplasm
02/2015
1Gouty Arthritis
01/2015
1Chondrocalcinosis (Pseudogout)
01/2015
1Arthritis (Polyarthritis)
01/2015
1Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
09/2014
1Transthyretin-Related Hereditary Amyloidosis
11/2013
1Immunoglobulin Light-chain Amyloidosis
11/2013
1Heart Failure
11/2013
1Toxoplasmosis
10/2013
1Chronic Granulomatous Disease
06/2013
1Cryoglobulinemia
04/2013
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
04/2013
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
02/2013
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
02/2013
1Multiple Organ Failure (MODS)
02/2013
1Iron-Deficiency Anemia (Anemia, Iron Deficiency)
01/2013

Drug/Important Bio-Agent (IBA)

10masitinibIBA
01/2018 - 11/2008
6Biological ProductsIBA
09/2019 - 04/2003
5Tryptases (Tryptase)IBA
01/2021 - 05/2005
5Rituximab (Mabthera)FDA Link
11/2016 - 08/2012
5Tyrosine Kinase InhibitorsIBA
09/2014 - 09/2003
4Pharmaceutical PreparationsIBA
01/2018 - 11/2002
4fludarabineIBA
04/2013 - 04/2000
4Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)IBA
03/2011 - 09/2003
4Interferon-alpha (Interferon Alfa)IBA
08/2007 - 04/2000
3CytokinesIBA
01/2018 - 01/2000
3Adrenal Cortex Hormones (Corticosteroids)IBA
11/2016 - 06/2004
3Imatinib Mesylate (Gleevec)FDA Link
09/2014 - 09/2003
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
04/2013 - 11/2005
3Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
06/2012 - 08/2009
3ErythropoietinFDA Link
02/2012 - 01/2005
3Monoclonal AntibodiesIBA
02/2010 - 05/2002
2Oxygen (Dioxygen)IBA
06/2017 - 02/2012
2Proteins (Proteins, Gene)FDA Link
06/2017 - 03/2008
2Tryptophan (L-Tryptophan)FDA Link
11/2016 - 03/2016
2Cytarabine (Cytosar-U)FDA LinkGeneric
01/2016 - 06/2004
2GemcitabineFDA Link
06/2015 - 01/2012
2Doxorubicin (Adriamycin)FDA LinkGeneric
08/2012 - 01/2012
2Arsenic Trioxide (Trisenox)FDA Link
08/2007 - 09/2004
2Oncogene Proteins (Oncogene Protein)IBA
01/2007 - 10/2000
1Abatacept (Orencia)FDA Link
01/2022
1tocilizumab (atlizumab)FDA Link
01/2021
1OvalbuminIBA
12/2018
1Serotonin (5 Hydroxytryptamine)IBA
11/2016
1KynurenineIBA
03/2016
1Acyl-CoA OxidaseIBA
06/2015
1Durapatite (Hydroxylapatite)IBA
01/2015
1Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
01/2015
1TroponinIBA
11/2013
1AA amyloidosisIBA
11/2013
1Adenosine (Adenocard)FDA LinkGeneric
10/2013
1CatalaseIBA
06/2013
1NADPH Oxidases (NAD(P)H oxidase)IBA
06/2013
1Phosphotransferases (Kinase)IBA
02/2013
1IronIBA
01/2013
1Prednisone (Sone)FDA LinkGeneric
08/2012

Therapy/Procedure

28Therapeutics
02/2015 - 10/2000
9Drug Therapy (Chemotherapy)
09/2016 - 10/2000
4Stem Cell Transplantation
09/2016 - 04/2002
3Kidney Transplantation
07/2010 - 11/2000
3Bone Marrow Transplantation (Transplantation, Bone Marrow)
02/2010 - 12/2002
2Hematopoietic Stem Cell Transplantation
01/2017 - 11/2005
2Aftercare (After-Treatment)
02/2010 - 03/2009
1Duration of Therapy
01/2015
1Cell Transplantation
05/2014
1Transplantation
05/2014
1Homologous Transplantation
05/2014
1Chemoprevention
10/2013